How would you treat the lesions of CMV retinitis ?
• Therapy with intravenous ganciclovir or foscarnet is given lifelong to protect unaffected areas but does not restore functional areas already affected. The optimal treatment for patients with AIDS, normal renal function and CMV retinitis is foscarnet plus an antiretroviral nucleoside such as zidovudine. For similar patients with impaired renal function, ganciclovir would be the drug of choice, perhaps with an antiretroviral agent such as didanosine that has few over-lapping side-effects. Late retinal detachment occurs despite therapy in one fifth of these patients.
• Sustained release ganciclovir implant in the pars plana of the eye. Oral ganciclovir in conjunction with an implant reduces the incidence of new cytomegalovirus disease and delays the progression of retinitis (N Engl J Med 1999; 340: 1063-70).
• Intravitreal injections of ganciclovir or foscarnet.
Lexo edhe:
• Therapy with intravenous ganciclovir or foscarnet is given lifelong to protect unaffected areas but does not restore functional areas already affected. The optimal treatment for patients with AIDS, normal renal function and CMV retinitis is foscarnet plus an antiretroviral nucleoside such as zidovudine. For similar patients with impaired renal function, ganciclovir would be the drug of choice, perhaps with an antiretroviral agent such as didanosine that has few over-lapping side-effects. Late retinal detachment occurs despite therapy in one fifth of these patients.
• Sustained release ganciclovir implant in the pars plana of the eye. Oral ganciclovir in conjunction with an implant reduces the incidence of new cytomegalovirus disease and delays the progression of retinitis (N Engl J Med 1999; 340: 1063-70).
• Intravitreal injections of ganciclovir or foscarnet.
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Lexo edhe: