• Hypertrophic cardiomyopathy is an autosomal dominant heart muscle disorder.
• Mutations in the gene encoding contractile proteins cause disease in 50-60'7c of patients.
• There are mutations in the gene encoding for myofibrillary proteins: at least 9 individual genes have been identified.
Beta heavy chain myosin gene mutations are associated with left ventricular outflow obstruction, whereas troponin T mutations are associated with rather modest left ventricular wall thickening, and mutations in myosin binding protein C are associated with onset in late adult life. Arginine gene mutations have a worse prognosis than leucine gene mutations.