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What is the role of heparin with thrombolysis ?

What is the role of heparin with thrombolysis ? 

In the ISIS-3 (Lancet 1992; 339: 753-70) and G1SSI-2 (Lancet 1990; 336: 65-75) studies heparin therapy with streptokinase or anistreplase was not beneficial, and it is believed that it may even be harmful. The GUSTO trial showed that, with tPA, early intravenous heparin results in a further reduction in the mortality rate compared with that found with a combination of heparin and streptokinase.

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