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What is the benefit of late administration of thrombolytic therapy ?

What is the benefit of late administration of thrombolytic therapy ? 

ISIS-2 (Lancet 1988; ii:349-60) showed benefit for up to 24 hours (after onset of symptoms) with thrombolysis, but more recent studies - LATE (Late Assessment of Thrombolytic Therapy) and EMRAS (Estudio Multicentrico Esteptoquinasa Republicas de America del Sur) - have shown no benefit for treatment given beyond 12 hours.

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