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What is the role of calcium channel blockers in the treatment of hypertension ?

What is the role of calcium channel blockers in the treatment of hypertension ?

• In the SYST-EUR study nitrendipine showed a reduction in the risk of stroke
inisolated systolic hypertension when compared to diuretics (Lancet 1997; 350: 757-64).

• In the Swedish Trial in Old Patients with Hypertension-2 (STOP-2) study, there was some evidence that the risks of myocardial infarction and of heart failure were greater with calcium antagonist based therapy than with ACE-inhibitor based therapy, but there were no clear differences between either of these regimens and a third based on diuretics and beta-blockers (Lancet 1999; 354: 1751-6). In this study 34-39% of patients withdrew from the three treatment regimens.

• The International Nifedipine GITS Study: Intervention as a Goal in Hypertension Treatment
(INSIGHT) trial compared long-acting nifedipine with a diuretic (hydrochlorothiazide and amiloride combination) and found that the calcium channel antagonist was as effective as diuretics in pr…

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