What is the role of troponins in the diagnosis of myocardial infarction ?
Raised concentrations of the myocardial regulatory protein troponin I are highly specific for myocardial injury. Estimation of troponin I concentration may be par-ticularly useful in patients with acute or chronic skeletal muscle disease or those with renal failure in whom the CK-MB (MB isoenzyme of creatine kinase) level may be raised in the absence of myocardial infarction. The measurement of troponin 1 is a sensitive and specific method (more specific than CK-MB) in the setting of perioperative myocardial infarction. Troponin T is also useful because it has a large diagnostic window, as it is increased from 12 hours to 10 days after myocardial infarction.
Lexo edhe:
Raised concentrations of the myocardial regulatory protein troponin I are highly specific for myocardial injury. Estimation of troponin I concentration may be par-ticularly useful in patients with acute or chronic skeletal muscle disease or those with renal failure in whom the CK-MB (MB isoenzyme of creatine kinase) level may be raised in the absence of myocardial infarction. The measurement of troponin 1 is a sensitive and specific method (more specific than CK-MB) in the setting of perioperative myocardial infarction. Troponin T is also useful because it has a large diagnostic window, as it is increased from 12 hours to 10 days after myocardial infarction.
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