What is the role of glycoprotein lib/Ilia antagonists as adjuncts to thrombolytic therapy in acute MI ?
What is the role of glycoprotein lib/Ilia antagonists as adjuncts to thrombolytic therapy in acute
MI ?
After thrombolytic therapy for acute MI, full anterograde perfusion (TIMI grade 3 flow) occurs in only 29-54% of patients at 90 minutes while reocclusion occurs in at least 12%, with increased morbidity and mortality.
Thrombolytic therapy may itself be prothrombotic by releasing clot-bound thrombin, which in turn stimulates platelet activation. Preclinical and early clinical trials have suggested that glycoprotein llb/llla receptor blockers (which prevent fibrinogen binding to platelets) used as adjuncts to thrombolytic therapy may improve early patency and reduce the incidence of reocclusion. A large randomized trial has recently confirmed the early findings on patency and suggests that adjunctive treatment with glycoprotein Ilb/IIIa receptor blockers may hold promise for better management of acute MI. The results from the GUSTO-AMI phase III trial using abciximab with reduced dose reteplase are awaited.
Lexo edhe:
After thrombolytic therapy for acute MI, full anterograde perfusion (TIMI grade 3 flow) occurs in only 29-54% of patients at 90 minutes while reocclusion occurs in at least 12%, with increased morbidity and mortality.
Thrombolytic therapy may itself be prothrombotic by releasing clot-bound thrombin, which in turn stimulates platelet activation. Preclinical and early clinical trials have suggested that glycoprotein llb/llla receptor blockers (which prevent fibrinogen binding to platelets) used as adjuncts to thrombolytic therapy may improve early patency and reduce the incidence of reocclusion. A large randomized trial has recently confirmed the early findings on patency and suggests that adjunctive treatment with glycoprotein Ilb/IIIa receptor blockers may hold promise for better management of acute MI. The results from the GUSTO-AMI phase III trial using abciximab with reduced dose reteplase are awaited.
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Lexo edhe:
